Gocha Golubiani

Gocha Golubiani


Academic Biography:

  • born in 1992 in Rustavi, Georgia
  • Bachelor’s Studies: Biology, Ilia State University Tbilisi, Faculty of Natural Sciences and Engineering, from 2011 to 2015
  • Master’s Studies: Molecular Biosciences, Ilia State University Tbilisi, Faculty of Natural Sciences and Engineering, Experimental Diploma: “Study of Cognin Interactome in Chick Brain”, from 2015 to 2017
  • Scientific Position(s): Laboratory Assistant, Laboratory of Molecular Genetics, Ilia State University, from 2015 to 2016
  • Laboratory Assistant, Institute of Chemical Biology, Ilia State University, from 2016 to 2018

Brief Description of the Doctoral Project:

„Comparative Study of the Mitochondrial Proteome in Rett Syndrome Mouse Model“

Rett syndrome is a neural development disorder  coused by spontanaous mutation in Gene MECP2 (methylated CpG binding protein), whic is located in chromosome X. The Majority of patients are young girls, as boys tend to die soon after birth because of acute state of disorder. Rett syndrome patients do not suffer with neurodegenerative process, instead, due to neurons abnormal small size and danced packaging brain volume is shruncked and neural structures weakened.
Rett syndrome patients development is normal during first 6 to 16 month of life. After that, several signs, such as mental problems and lack of communication are shown, which later is followed by number of severe disorders: sleep and breathing problems, labored movements, frequent epilepsies and seizures, body weight lose, scoliosis and stereotypic hand movements.Tissue analyses of  Rett syndrome patients show, that mitochondrial structure is damaged and functions  are  hindered and do not functions efficently. There is no cure for this disease. The only known way to mittigate the simptoms is adminstrating antioxidants.
The research will be done on males of ill and healthy mice. The selection of males is based on the knowledge that male mice exhibit Rett Syndrome features more strongly and earlier than females. The main topic of research is the comparative study of proteomic composition of mitochondria from the ill and healty mice brain. We will try to identify if there is any differance, quantitive or structural, in mitochondrial proteins.

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