Published works of the Institute of Chemical Biology

1. Solomonia R., Apkhazava D., Nozadze M., Jackson A.P., McCabe B.J., Horn G. “Different Forms of MARCKS Protein Are Involved in Memory Formation in the Learning Process of Imprinting”. Exp Brain Res. 188 (2008): 323–330
2. Zhvania M.G., Bolqvadze T, Solomonia R.O., Kuchiashvili N, Japaridze N.J. “Effect of Acoustic Stimulation on GABAergic Neurons in Limbic Structures of Krushinskii-Molodkina Rats”. Bull ExpBiol Med. 145 (2008): 398-400.
3. Zhuravliova E. Barbakadze T., Zaalishvili E, Koshoridze N., Chipashvili M., Mikeladze D Social isolation stress in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase. Experimental Brain Research. 205 (2009) 377–383
4. Kvaratskhelia E., Maisuradze E., Dabrundashvili NG, Natsvlishvili N, Zhuravliova E., Mikeladze DG. N-Methyl-D-Aspartate and sigma -Ligands Change the Production of Interleukins 8 and 10 in Lymphocytes through Modulation of the NMDA Glutamate Receptor.Neuroimmunomodulation, 2009;16:201-207
5. Zhuravliova E., T. Barbakadze T., Narmania N, Sepashvili M, Mikeladze D.G. Hypoinsulinemia Alleviates the Grf1/Ras/Akt Anti-Apoptotic Pathway and Induces Alterations of Mitochondrial Ras Trafficking in Neuronal Cells. Neurochemical Research , 2009, 34:1076–1082
6. Kharlamov EA., Lepsveridze E., Meparishvili M., Solomonia RO., Lu B., Miller ER., Kelly KM., Mtchedlishvili Z. “Alterations of GABA(A) and Glutamate Receptor Subunits and Heat Shock Protein in Rat Hippocampus Following Traumatic Brain Injury and in Posttraumatic Epilepsy”. Epilepsy Res. 95 (2011): 20-34
7. Solomonia RO., Kunelauri N., Mikautadze E., Apkhazava D., McCabe BJ., Horn G. “Mitochondrial Proteins, Learning and Memory: Biochemical Specialization of a Memory System”. Neuroscience 194 (2011): 112-123
8. Shanshiashvili L, Narmania N, Barbakadze T, Zhuravliova E, Natsvlishvili N, Ramsden J, Mikeladze DG. S-nitrosylation decreases the adsorption of H-Ras in lipid bilayer and changes intrinsic catalytic activity. Cell Biochemistry and Biophysics. 59(3):191-9, 2011.
9. Solomonia R., Mikautadze E., Nozadze M., Kuchiashvili N., Lepsveridze E., Kiguradze T. "Myo-Inositol Treatment Prevents Biochemical Changes Triggered by Kainate-Induced Status Epilepticus”. Neuroscience Letters 468 (2010): 277-281
10. Davitashvili E., Kvitsinadze N., Megrelishvili I., Karazanashvili G., Solomonia R., Aleksidze N. “Influence of Beta-Galactose-Specific Mitochondrial Lectins From Prostate Hyperplasic Tissue on Mitochondrial Properties.” The Scandinavian Journal of Clinical & Laboratory Investigation 70, (2010): 33-39
11. Nozadze M., Mikautadze E., Lepsveridze E., Mikeladze E., Kuchiashvili N., Kiguradze T., Kikvidze M., &Solomonia R. “Anticonvulsant Activities of myo-Inositol and scyllo-Inositol on Pentylenetetrazol Induced Seizures”. Seizure: European Journal of Epilepsy 20 (2011): 173-176
12. Cho WJ, Lee JS, Zhang L, Ren G, Shin L, Manke CW, Potoff J, Kotaria N, Zhvania MG, Jena BP. Membrane-directed molecular assembly of the neuronal SNARE complex. J. Cell Mol Med. 15, 1 13-17, 2011.
13. Shanshiashvili LV, Dabrundashvili N, Natsvlishvili N, Kvaratskhelia E, Zhuravliova E, Barbakadze T, Koriauli S, Maisuradze E, Topuria T, Mikeladze DG. mGluR1 interacts with cystic fibrosis transmembrane conductance regulator and modulates the secretion of IL-10 in cystic fibrosis peripheral lymphocytes. Molecular Immunology. 51(3-4): 310-315, 2012.
14. Azmaiparashvili E, Berishvili E, Kakabadze Z, Pilishvili O, Mikautadze E, Solomonia R, Jangavadze M, Kordzaia D. (2012) Ductular reaction at the early terms of common bile duct ligation in the rats. ActaBiol Hung, 63,321-332
15. Zhuravliova E, Barbakadze T, Jojua N, Zaalishvili E, Shanshiashvili L, Natsvlishvili N, Kalandadze I, Narmania N, Chogovadze I, Mikeladze D. Synaptic and Non-Synaptic Mitochondria in Hippocampus of Adult Rats Differ in Their Sensitivity to Hypothyroidism. Cellular and Molecular Neurobiology. 32:1311–1321, 2012
16. Shanshiashvili LV, Kalandadze IV, Ramsden JJ, Mikeladze DG. Adhesive Properties and Inflammatory Potential of Citrullinated Myelin Basic Protein Peptide 45-89. Neurochemcal Research. 37, 1959-1966, 2012.
17. Bátor J, Varga J, Berta G, Barbakadze T, Mikeladze D, Ramsden J, Szeberényi J. Sodium nitroprusside, a nitric oxide donor, fails to bypass the block of neuronal differentiation in PC12 cells imposed by a dominant negative Ras protein. Cellular and Molecular Biology Letters. 17(3):323-32, 2012.
18. Japaridze NJ, Okuneva VG, Qsovreli MG, Surmava AG, Lordkipanidze TG, Kiladze MT, Zhvania MG. Hypokinetic stress and neuronal porosome complex in the rat brain: the electron microscopic study. Micron, 2012, 43, 9, 948-954, 2012.
19. V.G. Okuneva, N.J. Japaridze, N.T. Kotaria, and M.G. Zhvania.Neuronal Porosome in the Rat and Cat Brain.Cell and Tissue Biology.2012, 6, 1, 69-72, 2012.
20. Okuneva VG, Dzhaparidze ND, Kotaria NT, Zhvaniia MG. Neuronal porosome in the rat and cat brain.Tsitologiia.254, 4, 324-328, 2012.
21. Zhvania MG, Chilachava LR, Japaridze NJ, Gelazonia LK, Lordkipanidze TG. Immediate and persisting effect of toluene chronic exposure on hippocampal cell loss in adolescent and adult rats.Brain Research Bulletins, 87, 2, 187-192, 2012.
22. M.G. Zhvania, N.J. Japaridze, M. Ksovreli, M. Kiladze, V. Okuneva, A. Surmava, T. Lordkipanidze, N. Kotaria. Effect of chronic hypokinetic stress on the structure of axo-dendritic synapses in the central nucleus of the amygdala of the rat: an electron microscopic investigation. Journal of Biological Physics and Chemistry, 12, 4, 148-152, 2012.
23. T. Z. Bikashvili, L. R., Chilachava, L. K. Gelazonia, N. J. Japaridze, M. G. Zhvania, T. G. Lordkipanidze and Okuneva V. G., Effectof Chronic Inhalation of Toluene on Behavior of Rats of Various Age Groups in MultiBranched Maze. Bulletin of Experimental Biology and Medicine, 152, 5, 587-589 (Translated in USA in English), 2012.
24. Barbakadze T, Natsvlishvili N, Mikeladze D. Thyroid hormones differentially regulate phosphorylation of ERK and Akt via integrin avß3 receptor in undifferentiated and differentiated PC-12 cells. Cell Biochemistry and Function. DOI: 10.1002/cbf.3013, 2013
25. Mzia G. Zhvania, Nadezhda J, Japaridze, Lela R. Chilachava, Lia K. Gelazonia, Tamar Z. Bikashvili, Manana G. Dashniani, Maia Burjanadze. Immediate and persisting effect of toluene chronic exposure on recognition memory, locomotor activity, behavior in multibranch maze and hippocampal Book: Toluene: Chemical Properties, Applications and Toxicology. Nova Science Publishers, Inc., Marco C. Palminteri USA. p. 53-92, 2013.
26. Kotaria N, Kiladze M, Zhvania MG, Japaridze NJ, Bikashvili T, Solomonia RO, Zhvania M, Bolkvadze T. The protective effect of Myo-inositol on hippocampal cell loss and structural alterations in neurons and synapses triggered by kainic acid-induced status epilepticus, Cell MolNeurobiol. 33(5):659-71, 2013.
27. Lordkipanidze T, Bikashvili T, Japaridze N,, ZhvaniaM.TheEffectofkainic acid on hippocampal dendritic spine motility at the early and late stages of development, Micron, 49, 28-32, 2013.
28. Solomonia, R., Gogichaishvili, N.,Nozadze M.,Lepsveridze E., Dzneladze D., Kiguradze T. Myo-Inositol Treatment and GABA-A Receptor Subunit Change After Kainate-Induced Status Epilepticus. Cellular and Molecular Neurobiology, 33, 119-127, 2013
29. Solomonia RO, Meparishvili M, Mikautadze E, Kunelauri N, Apkhazava D, McCabe BJ. (2013) AMPA receptor phosphorylation and recognition memory: learning-related, time-dependent changes in the chick brain following filial imprinting. Experimental Brain Research. 226,297-308
30. Kotaria N, Kiladze M, Zhvania MG, Japaridze NJ, Bikashvili T, Solomonia RO, Bolkvadze T. (2013) The protective effect of Myo-Inositol on hippocampal cell loss and structural alterations in neurons and synapses triggered by kainic acid-induced status epilepticus. Cellular and Molecular Neurobiology, 33,:659-71
31. Solomonia, R., Lepsveridze, E., Kiguradze, T. Nozadze, M. (2013) Inositols and Epilepsy In “Inositol: Synthesis, Functions and Clinical Implications” Eds: H.Rocha and M.Cardoso. NOVA Publishers,pp.105-128, (
32. Jojua N., Sharikadze N., Zhuravliova E., Zaalishvili E., Mikeladze D.G. Nobiletin restores impaired hippocampal mitochondrial bioenergetics in hypothyroidism through activation of matrix substrate-level phosphorylation. Nutritional Neuroscience, 2014, DOI: 10.1179/1476830514Y.0000000120; PMID: 24627959
33. Babuadze G, Alvar J, Argaw D, de Koning HP, Iosava M, Kekelidze M, Tsertsvadze N, Tsereteli D, Chakhunashvili G, Mamatsashvili T, Beria N, Kalandadze I, Ejov M, Imnadze P. Epidemiology of visceral leishmaniasis in Georgia. PLoSNegl Trop Dis. 2014 Mar 6;8(3):e2725. doi: 10.1371/journal.pntd.0002725.
34. MziaZhvania, Tamar Lordkipanidze, Maia Kiladze, NadezhdaJaparidze, NatoKotaria, Tamar Bikashvili – The Effect of kainic acid on the rat brain: histological, Electron-microscopic and Two-photon microscopic study. in Book: Kanic Acid: Neurotoxic Properties, Biological Sources and Clinical Applications. Nova Science Publishers, Inc.USA, (Book ID: 4939) (accepted for publication), 2014.
35. MziaZhvania, NadezhdaJaparidze, Mariam Ksovreli – Effect of different forms of hypokinezia on the ultrastructure of limbic, nbeocortical and extrapyramidal structures of the rat brain. Proceedings of Physics.Springer International Publishing Switzerland (Accepted for publication), 2014.
36. Mzia G. Zhvania, Nadezhda J. Japaridze, Mariam G, Qsovreli, Vera G. Okuneva, Arkadi G. Surmava, Tamar G. Lordkipanidze. The Neuronal Porosome Complex in Mammalian Brain: A Study Using Electron Microscopy. Chapter: NanoCell Biology: Multimodal Imaging in Biology and Medicine. Editors: Jena B.P., Taatjes D.J. Pan Stanford Publishing Pte. Ltd. In: Neuronal Porosome Complex, (2014 April).
37. Gegelashvili G and BjerrumOJ  High-affinity glutamate transporters in chronic pain: an emerging therapeutic target. Journal of Neurochemistry, 2014, doi: 10.1111/jnc.12957.
38. Toft-Kehler AK, Skytt DM, Poulsen KA, Brændstrup CT,  Gegelashvili G, Waagepetersen H, Kolko M. Limited energy supply in Müller cells alters glutamate uptake. Neurochemical  Research, 2014, 39(5):941.

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