ილიას სახელმწიფო უნივერსიტეტი

გამოქვეყნებული ნაშრომები

ქიმიური ბიოლოგიის ინსტიტუტის გამოქვეყნებული ნაშრომები

  1. Solomonia R., Apkhazava D., Nozadze M., Jackson A.P., McCabe B.J., Horn G. “Different Forms of MARCKS Protein Are Involved in Memory Formation in the Learning Process of Imprinting”. Exp Brain Res. 188 (2008): 323–330
  2. Zhvania M.G., Bolqvadze T, Solomonia R.O., Kuchiashvili N, Japaridze N.J. “Effect of Acoustic Stimulation on GABAergic Neurons in Limbic Structures of Krushinskii-Molodkina Rats”. Bull Exp Biol Med. 145 (2008): 398-400.
  3.  Zhuravliova E. Barbakadze T., Zaalishvili E, Koshoridze N., Chipashvili M., Mikeladze D Social isolation stress in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase. Experimental Brain Research. 205 (2009) 377–383
  4.  Kvaratskhelia E., Maisuradze E., Dabrundashvili NG, Natsvlishvili N, Zhuravliova E., Mikeladze DG. N-Methyl-D-Aspartate and sigma -Ligands Change the Production of Interleukins 8 and 10 in Lymphocytes through Modulation of the NMDA Glutamate Receptor. Neuroimmunomodulation, 2009;16:201-207 
  5. Zhuravliova E., T. Barbakadze T., Narmania N, Sepashvili M, Mikeladze D.G. Hypoinsulinemia Alleviates the Grf1/Ras/Akt Anti-Apoptotic Pathway and Induces Alterations of Mitochondrial Ras Trafficking in Neuronal Cells. Neurochemical Research , 2009, 34:1076–1082
  6. Kharlamov EA., Lepsveridze E., Meparishvili M., Solomonia RO., Lu B., Miller ER., Kelly KM., Mtchedlishvili Z. “Alterations of GABA(A) and Glutamate Receptor Subunits and Heat Shock Protein in Rat Hippocampus Following Traumatic Brain Injury and in Posttraumatic Epilepsy”. Epilepsy Res. 95 (2011): 20-34
  7.  Solomonia RO., Kunelauri N., Mikautadze E., Apkhazava D., McCabe BJ., Horn G. “Mitochondrial Proteins, Learning and Memory: Biochemical Specialization of a Memory System”. Neuroscience 194 (2011): 112-123
  8. Shanshiashvili L, Narmania N, Barbakadze T, Zhuravliova E, Natsvlishvili N, Ramsden J, Mikeladze DG. S-nitrosylation decreases the adsorption of H-Ras in lipid bilayer and changes intrinsic catalytic activity. Cell Biochemistry and Biophysics. 59(3):191-9, 2011.
  9. Solomonia R., Mikautadze E., Nozadze M., Kuchiashvili N., Lepsveridze E., Kiguradze T. "Myo-Inositol Treatment Prevents Biochemical Changes Triggered by Kainate-Induced Status Epilepticus”. Neuroscience Letters 468 (2010): 277-281 
  10. Davitashvili E., Kvitsinadze N., Megrelishvili I., Karazanashvili G., Solomonia R., Aleksidze N. “Influence of Beta-Galactose-Specific Mitochondrial Lectins From Prostate Hyperplasic Tissue on Mitochondrial Properties.” The Scandinavian Journal of Clinical & Laboratory Investigation 70, (2010): 33-39
  11. Nozadze M., Mikautadze E., Lepsveridze E., Mikeladze E., Kuchiashvili N., Kiguradze T., Kikvidze M., & Solomonia R. “Anticonvulsant Activities of myo-Inositol and scyllo-Inositol on Pentylenetetrazol Induced Seizures”. Seizure: European Journal of Epilepsy 20 (2011): 173-176
  12. Cho WJ, Lee JS, Zhang L, Ren G, Shin L, Manke CW, Potoff J, Kotaria N, Zhvania MG, Jena BP. Membrane-directed molecular assembly of the neuronal SNARE complex. J. Cell Mol Med. 15, 1 13-17, 2011.
  13. Shanshiashvili LV, Dabrundashvili N, Natsvlishvili N, Kvaratskhelia E, Zhuravliova E, Barbakadze T, Koriauli S, Maisuradze E, Topuria T, Mikeladze DG. mGluR1 interacts with cystic fibrosis transmembrane conductance regulator and modulates the secretion of IL-10 in cystic fibrosis peripheral lymphocytes. Molecular Immunology. 51(3-4): 310-315, 2012.
  14. Azmaiparashvili E, Berishvili E, Kakabadze Z, Pilishvili O, Mikautadze E, Solomonia R, Jangavadze M, Kordzaia D. (2012) Ductular reaction at the early terms of common bile duct ligation in the rats. Acta Biol Hung, 63,321-332
  15. Zhuravliova E, Barbakadze T, Jojua N, Zaalishvili E, Shanshiashvili L, Natsvlishvili N, Kalandadze I, Narmania N, Chogovadze I, Mikeladze D. Synaptic and Non-Synaptic Mitochondria in Hippocampus of Adult Rats Differ in Their Sensitivity to Hypothyroidism. Cellular and Molecular Neurobiology. 32:1311–1321, 2012
  16. Shanshiashvili LV, Kalandadze IV, Ramsden JJ, Mikeladze DG. Adhesive Properties and Inflammatory Potential of Citrullinated Myelin Basic Protein Peptide 45-89. Neurochemcal Research. 37, 1959-1966, 2012. 
  17. Bátor J, Varga J, Berta G, Barbakadze T, Mikeladze D, Ramsden J, Szeberényi J. Sodium nitroprusside, a nitric oxide donor, fails to bypass the block of neuronal differentiation in PC12 cells imposed by a dominant negative Ras protein. Cellular and Molecular Biology Letters. 17(3):323-32, 2012.
  18.  Japaridze NJ, Okuneva VG, Qsovreli MG, Surmava AG, Lordkipanidze TG, Kiladze MT, Zhvania MG. Hypokinetic stress and neuronal porosome complex in the rat brain: the electron microscopic study. Micron, 2012, 43, 9, 948-954, 2012.
  19. V.G. Okuneva, N.J. Japaridze, N.T. Kotaria, and M.G. Zhvania. Neuronal Porosome in the Rat and Cat Brain. Cell and Tissue Biology. 2012, 6, 1, 69-72, 2012.
  20. Okuneva VG, Dzhaparidze ND, Kotaria NT, Zhvaniia MG. Neuronal porosome in the rat and cat brain. Tsitologiia. 254, 4, 324-328, 2012.
  21. Zhvania MG, Chilachava LR, Japaridze NJ, Gelazonia LK, Lordkipanidze TG. Immediate and persisting effect of toluene chronic exposure on hippocampal cell loss in adolescent and adult rats. Brain Research Bulletins, 87, 2, 187-192, 2012.
  22. M.G. Zhvania, N.J. Japaridze, M. Ksovreli, M. Kiladze, V. Okuneva, A. Surmava, T. Lordkipanidze, N. Kotaria. Effect of chronic hypokinetic stress on the structure of axo-dendritic synapses in the central nucleus of the amygdala of the rat: an electron microscopic investigation. Journal of Biological Physics and Chemistry, 12, 4, 148-152, 2012.
  23. T. Z. Bikashvili, L. R., Chilachava, L. K. Gelazonia, N. J. Japaridze, M. G. Zhvania, T. G. Lordkipanidze and Okuneva V. G., Effectof Chronic Inhalation of Toluene on Behavior of Rats of Various Age Groups in MultiBranched Maze. Bulletin of Experimental Biology and Medicine, 152, 5, 587-589 (Translated in USA in English), 2012.
  24. Barbakadze T, Natsvlishvili N, Mikeladze D. Thyroid hormones differentially regulate phosphorylation of ERK and Akt via integrin avß3 receptor in undifferentiated and differentiated PC-12 cells. Cell Biochemistry and Function. DOI: 10.1002/cbf.3013, 2013 
  25. Mzia G. Zhvania, Nadezhda J, Japaridze, Lela R. Chilachava, Lia K. Gelazonia, Tamar Z. Bikashvili, Manana G. Dashniani, Maia Burjanadze. Immediate and persisting effect of toluene chronic exposure on recognition memory, locomotor activity, behavior in multibranch maze and hippocampal structure. in Book: Toluene: Chemical Properties, Applications and Toxicology. Nova Science Publishers, Inc., Marco C. Palminteri USA. p. 53-92, 2013. 
  26. Kotaria N, Kiladze M, Zhvania MG, Japaridze NJ, Bikashvili T, Solomonia RO, Zhvania M, Bolkvadze T. The protective effect of Myo-inositol on hippocampal cell loss and structural alterations in neurons and synapses triggered by kainic acid-induced status epilepticus, Cell Mol Neurobiol. 33(5):659-71, 2013.
  27. Lordkipanidze T, Bikashvili T, Japaridze N,, Zhvania M.The Effectof kainic acid on hippocampal dendritic spine motility at the early and late stages of development, Micron, 49, 28-32, 2013.
  28. Solomonia, R., Gogichaishvili, N.,Nozadze M.,Lepsveridze E., Dzneladze D., Kiguradze T. Myo-Inositol Treatment and GABA-A Receptor Subunit Change After Kainate-Induced Status Epilepticus. Cellular and Molecular Neurobiology, 33, 119-127, 2013 
  29. Solomonia RO, Meparishvili M, Mikautadze E, Kunelauri N, Apkhazava D, McCabe BJ. (2013) AMPA receptor phosphorylation and recognition memory: learning-related, time-dependent changes in the chick brain following filial imprinting. Experimental Brain Research. 226,297-308
  30. Kotaria N, Kiladze M, Zhvania MG, Japaridze NJ, Bikashvili T, Solomonia RO, Bolkvadze T. (2013) The protective effect of Myo-Inositol on hippocampal cell loss and structural alterations in neurons and synapses triggered by kainic acid-induced status epilepticus. Cellular and Molecular Neurobiology, 33,:659-71
  31.  Solomonia, R., Lepsveridze, E., Kiguradze, T. Nozadze, M. (2013) Inositols and Epilepsy In “Inositol: Synthesis, Functions and Clinical Implications” Eds: H.Rocha and M.Cardoso. NOVA Publishers,pp.105-128, (https://www.novapublishers.com/catalog/product_info.php?products_id=39509
  32. Jojua N., Sharikadze N., Zhuravliova E., Zaalishvili E., Mikeladze D.G. Nobiletin restores impaired hippocampal mitochondrial bioenergetics in hypothyroidism through activation of matrix substrate-level phosphorylation. Nutritional Neuroscience, 2014, DOI: 10.1179/1476830514Y.0000000120; PMID: 24627959
  33. Babuadze G, Alvar J, Argaw D, de Koning HP, Iosava M, Kekelidze M, Tsertsvadze N, Tsereteli D, Chakhunashvili G, Mamatsashvili T, Beria N, Kalandadze I, Ejov M, Imnadze P. Epidemiology of visceral leishmaniasis in Georgia. PLoS Negl Trop Dis. 2014 Mar 6;8(3):e2725. doi: 10.1371/journal.pntd.0002725.
  34. Mzia Zhvania, Tamar Lordkipanidze, Maia Kiladze, Nadezhda Japaridze, Nato Kotaria, Tamar Bikashvili – The Effect of kainic acid on the rat brain: histological, Electron-microscopic and Two-photon microscopic study. in Book: Kanic Acid: Neurotoxic Properties, Biological Sources and Clinical Applications. Nova Science Publishers, Inc.USA, (Book ID: 4939) (accepted for publication), 2014.
  35. Mzia Zhvania, Nadezhda Japaridze, Mariam Ksovreli – Effect of different forms of hypokinezia on the ultrastructure of limbic, nbeocortical and extrapyramidal structures of the rat brain. Proceedings of Physics. Springer International Publishing Switzerland (Accepted for publication), 2014.
  36. Mzia G. Zhvania, Nadezhda J. Japaridze, Mariam G, Qsovreli, Vera G. Okuneva, Arkadi G. Surmava, Tamar G. Lordkipanidze. The Neuronal Porosome Complex in Mammalian Brain: A Study Using Electron Microscopy. Chapter: NanoCell Biology: Multimodal Imaging in Biology and Medicine. Editors: Jena B.P., Taatjes D.J. Pan Stanford Publishing Pte. Ltd. In: Neuronal Porosome Complex, (2014 April).
  37.  Gegelashvili G and Bjerrum OJ  High-affinity glutamate transporters in chronic pain: an emerging therapeutic target. Journal of Neurochemistry2014, doi: 10.1111/jnc.12957.
  38. Toft-Kehler AKSkytt DMPoulsen KABrændstrup CT,  Gegelashvili G, Waagepetersen HKolko M. Limited energy supply in Müller cells alters glutamate uptake. Neurochemical  Research2014, 39(5):941. 
  39. Molecular Mechanisms of memory in imprintingSolomonia RO, McCabe BJ.NeurosciBiobehav Rev. 2014 Oct 2: S0149-7634(14)00240-1. doi: 10.1016/j.neubiorev.2014.09.013. Review.
  40. Molecular phylogeny of hantaviruses harbored by insectivorous bats in Cote d’Ivoire and Vietnam Gu SH, Lim BK, Kadjo B, Arai S, Kim JA, Nicolas V, Lalis A, Denys C, Cook JA, Dominguez SR, Holmes KV, Urushadze L,Sidamonidze K, Putkaradze D, Kuzmin IV, Kosoy MY, Song JW, Yanagihara R.Viruses. 2014 Apr 29;6(5):1897-910. doi: 10.3390/v6051897
  41. Meparishvili M, Nozadze M, Margvelani G, McCabe BJ, Solomonia RO (2015) A Proteomic Study of Memory after imprinting in the domestic chick. Front Behav Neurosci. 2015 Nov 26;9:319. doi: 10.3389/fnbeh.2015.00319.
  42. Solomonia RO, McCabe BJ. “Molecular mechanisms of memory in imprintingNeurosci Biobehav Rev. 2015 Mar;50:56-69. doi: 10.1016/j.neubiorev.2014.09.013. Epub 2014 Oct 2. (სტატიის წინასწარი ვერსია 2014 წელს არის გამოქვეყნებული)
  43. Caballero-Garrido E, Pena-Philippides JC, Lordkipanidze T, Bragin D, Yang Y, Erhardt EB, Roitbak T. (2015) In vivo inhibition of miR-155 promotes recovery after experimental mouse stroke. J Neurosci. 2015 Sep 9;35(36):12446-64. 
  44. Kelly KM, Miller ER, Lepsveridze E, Kharlamov EA, Mchedlishvili Z. (2015) Posttraumatic seizures abd epilepsy in adult rats after controlled cortical impact. Epilepsy Res. 2015 Nov;117:104-16. doi: 10.1016/j.eplepsyres.2015.09.009. Epub 2015 Sep 11.
  45. Schmalbach B, Lepsveridze E, Djogo N, Papashvili G, Kuang F, Leshchyns'ka I, Sytnyk V, Nikonenko AG, Dityatev A, Jakovcevski I, Schachner M. (2015) Age-dependent loss of parvalbumin-expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene. J Neurochem. 2015 Nov;135(4):830-44. doi: 10.1111/jnc.13284. Epub 2015 Sep 
  46. Zhvania MG, Japaridze NJ, Qsovreli MG, Okuneva VG, Surmava AG, Lordkipanidze TG.(2015) Electron microscopic morphometry of isolated rat brain porosome complex Neurosci Res.Nov;100:17-20. doi: 10.1016/j.neures.2015.06.008. Epub 2015 Jun 25.
  47. Zhvania MG, Ksovreli M, Japaridze NJ, Lordkipanidze TG. Ultrastructural changes to rat hippocampus in pentylenetetrazol and kainic acid-induced status epilepticus: A study using electron microscopy Micron. 2015 Jul;74:22-9. doi: 10.1016/j.micron.2015.03.015. Epub 2015 Apr 8
  48. Datukishvili N, Kutateladze T, Gabriadze I, Bitskinashvili K, Vishnepolsky B. New multiplex PCR methods for rapid screening of genetically modified organisms in foods. Frontiers in Microbiology. 2015 Jul 24;6:757. doi: 10.3
  49. Gabriadze I., Kutateladze T., Vishnepolsky B., Karseladze M., Zaalishvili T., Datukishvili N., Muskhelishvili G. (2015) Polymerase Chain Reaction Based Assays for Specific Detection of Barley. Bulletin of the Georgian National Academy of Sciences, v. 9 (1), pp. 145-150 
  50. Natsvlishvili N., Goguadze N., Zhuravliova E., Mikeladze D. Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria., BMC Biochemistry, 2015, 16:11
  51. Koriauli S, Natsvlishvili N, Barbakadze T, Mikeladze D.Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons. Biological Research. 2015 Oct 9;48(1):55. doi: 10.1186/s40659-015-0048-1.
  52. Jojua N, Sharikadze N, Zhuravliova E, Zaalishvili E, Mikeladze DG.Nobiletin restores impaired hippocampal mitochondrial bioenergetics in hypothyroidism through activation of matrix substrate-level phosphorylation. Nutrition Neuroscience. 2015 Jul;18(5):225-31. doi: 10.1179/1476830514Y.0000000120
  53. Datukishvili N, Kutateladze T, Gabriadze I, Bitskinashvili K, Vishnepolsky B. New multiplex PCR methods for rapid screening of genetically modified organisms in foods. Frontiers in Microbiology. 2015 Jul 24;6:757. doi: 10.3
  54. Koriauli S, Natsvlishvili N, Barbakadze T, Mikeladze D.Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons. Biological Research. 2015 Oct 9;48(1):55. doi: 10.1186/s40659-015-0048-1.
  55. Nozadze M, Zhgenti E, Meparishvili M, Tsverava L, Kiguradze T, Chanturia G, Babuadze G, Kekelidze M, Bakanidze L, Shutkova T, Imnadze P, Francesconi SC, Obiso R and Solomonia R (2015) Comparative proteomic studies of Yersinia pestis strains isolated from natural foci in the Republic of Georgia. Front. Public Health 3:239. doi: 10.3389/fpubh.2015.00239
  56. Meparishvili M, Nozadze M, Margvelani G, McCabe BJ, Solomonia RO (2015) A Proteomic Study of Memory after imprinting in the domestic chick. Front Behav Neurosci. 2015 Nov 26;9:319. doi: 10.3389/fnbeh.2015.00319.
  57. Tsverava L., Lordkipanidze T., Lepsveridze E., Nozadze M. Kikvidze M. Solomonia R (2016) Myoinositol Attenuates the Cell Loss and Biochemical Changes Induced by Kainic Acid Status Epilepticus," BioMed Research International, vol. 2016, Article ID 2794096, 14 pages, 2016. doi:10.1155/2016/2794096.
  58. Babuadze G, Farlow J, de Koning HP, Carrillo E, Chakhunashvili G, Murskvaladze M, Kekelidze M, Karseladze I, Kokaia N, Kalandadze I, Tsereteli D, Markhvashvili I, Sidamonidze K, Chanturia G, Adeishvili E, Imnadze P. (2016) Seroepidemiology and molecular diversity of Leishmaniadonovani complex in Georgia.Parasit Vectors. 13;9(1):279. doi: 10.1186/s13071-016-1558-6
  59. Pena-Philippides JC, Caballero-Garrido E, Lordkipanidze T, Roitbak T.(2016)In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response.J Neuroinflammation.13 (1):287.
  60. Elene O. Tsitsilashvili, Lali V. Shanshiashvili, David G. Mikeladze. Macrophages – cells with broad potential. JBPC, Vol.16, 4, 2016 
  61. Nino Sharikadze, Natia Jojua, Maia Sepashvili, Elene Zhuravliova and David G Mikeladze. Mitochondrial Target of Nobiletin's Action, Natural Product Communications, 2016, 11(12), 1835-1839
  62. Tamar Barbakadze, Galina Goloshvili, Nana Narmania, Elene Zhuravliova, David Mikeladze. “Subcellular distribution of S-nitrosylated H-Ras in differentiated and undifferentiated PC12 cells during hypoxia“ - Cell Journal (Yakhteh) - in PressLali Shanshiashvili, Elene Tsitsilashvili, Nino Dabrundashvili, Irine Kalandadze and David Mikeladze. Metabotropic glutamate receptor 5 may be involved in macrophage plasticity. Biological Research 2017, 50:4 DOI: 10.1186/s40659-017-0110-2
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