Endogenous stem cells and Induced pluripotent stem cells in research and therapy : Current challenges and future prospects


Endogenous stem cells and Induced pluripotent stem cells in research and therapy : Current challenges and future  prospects

Shibashish Giri

Applied Stem Cell Biology and Cell Technology, Biomedical and Biotechnological Center, University of Leipzig. Germany.

Department of Plastic Surgery and Hand Surgery, University Hospital Rechts der Isar, Technische Universität München, Munich, Germany.

Abstract :

Activation of endogenous stem cells is more powerful and superior than allogenic/ autologous stem cell translation in term for organ regeneration.  Naturally, local endogenous stem cellactively contributes the regeneration of damaged cells/tissues/organs that represents a promising and successful platform in regenerative medicine. In principle, our local endogenous stem cells know much better how to regenerate the organ. Every organ has their own local endogenous stem cells, generally silent mode but active upon demand for organ regeneration. Identification and characterization of local endogenous stem cells and their activation for organ regeneration is a big challenge in stem cell research and therapy. Identification endogenous stem cells in various human organs such as skin, heart, brain, liver and kidney and characterized their regeneration potential in in vitro models, in vivo non-human model as well as human clinical setting is the main theme of our research and therapy. Like our immune system, endogenous stem cell system has also significant role for organ regeneration. Current modern life style hampers rapidly the regenerative  potential of our endogenous stem cells system. Various cases studies have been conducted for organ regeneration by changing healthy daily life styles. Taken all together, important role of endogenous stem cell is the central focus here. It is necessary to take good care of endogens stem cells system of our body and keep healthy daily life style to prevent from organ degeneration diseases as well as not to welcome the diseases.

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